Synthesis of 2 C-14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Synthesis of 2 C-14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole

Published:2017-05-18 Issue:6 Volume:60 Page:294-301
ISSN:0362-4803
Container-title:Journal of Labelled Compounds and Radiopharmaceuticals
language:en
Short-container-title:J. Label Compd. Radiopharm

Author:

Kingston Lee¹,Bergare Jonas¹,Lönn Hans²,Ericsson Cecilia¹,Grönberg Gunnar²,Chen Song³,Elmore Charles S.¹^ORCID

Affiliation:

1. Isotope Chemistry, Pharmaceutical Sciences iMED; AstraZeneca Pharmaceuticals AB; Mölndal Sweden

2. Medicinal Chemistry, Respiratory, Inflammation, and Autoimmune iMED; AstraZeneca Pharmaceuticals AB; Mölndal Sweden

3. Pharmaron Beijing Co., Ltd.; Beijing China

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jlcr.3502/fullpdf

Reference19 articles.

1. Cathepsin C inhibitors: property optimization and identification of a clinical candidate;Furber;J Med Chem,2014

2. Aortic binding of AZD5248: mechanistic insight and reactivity assays to support lead optimzation;Bragg;Chem Res Toxicol,2015

3. Covalent binding of radioactivity from [14C]Rofecoxib, but not from [14C]Celecoxib or [14C]CS-706, to the arterial elastin of rats;Oitate;Drug Metab Dispos,2006

4. Mechanism for covalent binding of rofecoxib to elastin of rat aorta;Oitate;J Pharmacol Exp Ther,2007

5. Discovery of second generation reversible covalent DPP1 inhibitors leading to an Oxazepane Amidoacetonitrile based clinical candidate (AZD7986);Doyle;J Med Chem,2016

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Die Zukunft (Radio‐)‐isotopenmarkierter Verbindungen in Forschung und Entwicklung der modernen Lebenswissenschaften;Angewandte Chemie;2023-10-04

2. The Future of (Radio)‐Labeled Compounds in Research and Development within the Life Science Industry;Angewandte Chemie International Edition;2023-10-04

3. In-vivo imaging of a mouse by detecting bremsstrahlung X-rays from 14C using a La-GPS imaging system;Journal of Nuclear Science and Technology;2022-03-30

4. The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects;Journal of Labelled Compounds and Radiopharmaceuticals;2021-01-07

5. Brensocatib. Dipeptidyl peptidase 1 (DPP1) inhibitor, Treatment of non-cystic fibrosis bronchiectasis;Drugs of the Future;2021

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号京ICP备18003416号-3