Lathyrus sativus diamine oxidase reduces Clostridium difficile toxin A‐induced toxicity in Caco‐2 cells by rescuing RhoA‐GTPase and inhibiting pp38‐MAPK / NF‐κB / HIF ‐1α activation

Author:

Pietrangeli Paola1,Corpetti Chiara2,Seguella Luisa2,Del Re Alessandro2,Pesce Marcella3,Vincenzi Martina2,Lori Chiara2,Annunziata Giuseppe4ORCID,Mateescu Mircea A.5,Sarnelli Giovanni3,Esposito Giuseppe2,Marcocci Lucia1

Affiliation:

1. Department of Biochemical Sciences “A. Rossi Fanelli”, Faculty of Pharmacy and Medicine Sapienza University of Rome Rome Italy

2. Department of Physiology and Pharmacology “V. Erspamer” Sapienza University of Rome Rome Italy

3. Department of Clinical Medicine and Surgery, section of Gastroenterology University Federico II Naples Italy

4. Department of Pharmacy University Federico II Naples Italy

5. Department of Chemistry and Centre CERMO‐FC Université du Québec à Montreal, CP8888 Branch A, Montreal (Québec) Montreal Québec Canada

Publisher

Wiley

Subject

Pharmacology

Reference30 articles.

1. Carboxymethyl starch: Chitosan monolithic matrices containing diamine oxidase and catalase for intestinal delivery

2. IL‐11 inhibits Clostridium difficile toxin a enterotoxicity in rat ileum;Castagliuolo I.;The American Journal of Physiology,1997

3. The role of toxins in Clostridium difficile infection

4. Rifaximin improves Clostridium difficile toxin A‐induced toxicity in Caco‐2 cells by the PXR‐dependent TLR4/MyD88/NF‐κB pathway;Esposito G.;Frontiers in Pharmacology,2016

5. The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

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