A phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone

Author:

Kremer Joel M.,Cohen Stanley,Wilkinson Bethanie E.,Connell Carol A.,French Jonathan L.,Gomez-Reino Juan,Gruben David,Kanik Keith S.,Krishnaswami Sriram,Pascual-Ramos Virginia,Wallenstein Gene,Zwillich Samuel H.

Publisher

Wiley

Subject

Pharmacology (medical),Immunology,Rheumatology,Immunology and Allergy

Reference17 articles.

1. Treating inflammation with the Janus kinase inhibitor CP-690,550;Vijayakrishnan;Trends Pharmacol Sci,2011

2. Janus kinases in immune cell signaling;Ghoreschi;Immunol Rev,2009

3. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis;Meyer;J Inflamm (Lond),2010

4. Li X Jesson M Lee J Hirsch J Saabye M Bonar S Characterization of a potent inhibitor of JAK kinases, CP-690,550, and inhibition of specific JAK/STAT pathways at efficacious exposures in a rodent model of arthritis 2008

5. The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo;Kremer;Arthritis Rheum,2009

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