Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation

Author:

Aizawa Koichi12,Liu Chun1,Tang Sanyuan1,Veeramachaneni Sudipta1,Hu Kang-Quan1,Smith Donald E.3,Wang Xiang-Dong1

Affiliation:

1. Nutrition and Cancer Biology Laboratory; Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University; Boston MA

2. Nature & Wellness Research Department; Research & Development Division, Kagome Co, Ltd; Tochigi Japan

3. Comparative Biology Unit; Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University; Boston MA

Funder

NIH/NCI

Universiteit Stellenbosch

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference53 articles.

1. Lung carcinogenesis by tobacco smoke;Hecht;Int J Cancer,2012

2. NNK-induced lung tumors: a review of animal model;Zheng;J Oncol,2011

3. Significance of reductases in the detoxification of the tobacco-specific carcinogen NNK;Maser;Trends Pharmacol Sci,2004

4. Connections of nicotine to cancer;Grando;Nat Rev Cancer,2014

5. Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N′-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone;Hecht;Cancer Res,1980

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