Therapy development in Huntington disease: From current strategies to emerging opportunities
Author:
Affiliation:
1. Departments of Neurology, Neurobiology, and Cell BiologyDuke Center for Neurodegeneration & NeurotherapeuticsDuke University Medical CenterDurhamNorth Carolina
Funder
National Institutes of Health
Publisher
Wiley
Subject
Genetics (clinical),Genetics
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajmg.a.38494
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1. Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis
2. A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
3. Preferential loss of striato-external pallidal projection neurons in presymptomatic Huntington's disease
4. Quetiapine in the Treatment of Behavioral Disturbances in Patients With Huntington’s Disease
5. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
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