Affiliation:
1. Molecular Synthesis Center, Key Laboratory of Marine Medicine, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China Qingdao Shandong 266003 China
2. Laboratory for Marine Drugs and Bioproducts National Laboratory for Marine Science and Technology Qingdao Shandong 266237 China
Abstract
Comprehensive SummaryA direct oxidative radical decarboxylative cyanomethylation of carboxylic acids is described using 3‐azido‐2‐methylbut‐3‐en‐2‐ol as the carbon‐centered radical acceptor. The transformation is applicable to structurally diverse α‐amino acids, α‐oxy acids, α‐keto acids, pentofuranuronic acids, and hexopyranuronic acids. The mechanistic investigations suggest that a radical process is involved in the transformation. This work provides a potential approach to β‐amino acid, 5‐deoxy‐hexofuranose, and 6‐deoxy‐heptose constructs of biological relevance.
Funder
National Natural Science Foundation of China
Cited by
2 articles.
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