Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant-Reference-Cited by-同舟云学术

Photoinduced Dehalocyclization to Access Oxindoles Using Formate as a Reductant

Published:2024-02-06 Issue:11 Volume:42 Page:1203-1208
ISSN:1001-604X
Container-title:Chinese Journal of Chemistry
language:en
Short-container-title:Chin. J. Chem.

Author:

Ge Wei¹,Wang Jia‐Xin¹,Fu Ming‐Chen¹²,Fu Yao¹

Affiliation:

1. Hefei National Research Center for Physical Sciences at the Microscale, iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Anhui Province Key Laboratory of Biomass Clean Energy University of Science and Technology of China Hefei Anhui 230026 China

2. Anhui Province Key Laboratory of Value‐Added Catalytic Conversion and Reaction Engineering Hefei University of Technology Hefei Anhui 230009 China

Abstract

Comprehensive SummaryHerein, we report an efficient and practical protocol for the photoinduced dehalocyclization of ortho‐halophenylacrylamides with formate by the engagement of a CO2 radical anion to access substituted oxindoles. This method proceeds smoothly under mild conditions and exhibits a wide range of substrate as well as remarkable functional group compatibility.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cjoc.202300740

Reference57 articles.

1. The Chemistry of Oxindole.

2. Anticholinesterase Activity of Compounds Related to Geneserine Tautomers. N-Oxides and 1,2-Oxazines

3. Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

4. 3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities

5. Recent advances in isatin hybrids as potential anticancer agents