Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria-Reference-Cited by-同舟云学术

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Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria

Published:2019-08-16 Issue:11 Volume:8 Page:815-824
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT Pharmacometrics Syst. Pharmacol.

Author:

Chauzy Alexia¹²,Gaelzer Silva Torres Bruna¹²,Buyck Julien¹²,Jonge Boudewijn³,Adier Christophe¹⁴,Marchand Sandrine¹²⁴,Couet William¹²⁴,Grégoire Nicolas¹²

Affiliation:

1. INSERM U1070 Pôle Biologie Santé Poitiers Cedex 9 France

2. Université de Poitiers UFR de Médecine Pharmacie Poitiers France

3. Pfizer Essential Health Cambridge Massachusetts USA

4. Laboratoire de Toxicologie‐Pharmacocinétique CHU de Poitiers Poitiers France

Funder

Seventh Framework Programme

European Federation of Pharmaceutical Industries and Associations

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12452

Reference20 articles.

1. In VitroActivity of Aztreonam-Avibactam against a Global Collection of Gram-Negative Pathogens from 2012 and 2013

2. OP0595, a new diazabicyclooctane: mode of action as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’

3. Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

4. Prediction ofin vivoandin vitroinfection model results using a semimechanistic model of avibactam and aztreonam combination against multidrug resistant organisms

5. A mathematical model-based analysis of the time–kill kinetics of ceftazidime/avibactam against Pseudomonas aeruginosa

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