The GluN2B‐Glu413Gly NMDA receptor variant arising from ade novo GRIN2Bmutation promotes ligand‐unbinding and domain opening
Author:
Affiliation:
1. African Health Research InstituteSteyn Lab, K‐RITH Tower, Nelson R. Mandela Medical School Durban South Africa
2. Department of ChemistryEmory University Atlanta Georgia
3. Department of PharmacologyEmory University Atlanta Georgia
Funder
National Institutes of Health-National Institute of Neurological Disorders and Stroke
National Institutes of Health-National Institute for Child Health and Human Development
National Research Foundation of South Africa
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/prot.25595
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3. An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder
4. Rationale for and use of NMDA receptor antagonists in Parkinson's disease
5. Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
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