Direct distinction of ibuprofen and flurbiprofen enantiomers by ion mobility mass spectrometry of their ternary complexes with metal cations and cyclodextrins in the gas phase

Author:

Gu Liancheng12,Wu Fangling1,Yang Shutong12ORCID,Xu Fuxing1,Dai Xinhua3,Jiang You3,Fang Xiang3,Yu Shaoning1,Ding Chuan‐Fan1

Affiliation:

1. Zhejiang Provincial Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis, Institute of Mass Spectrometry, School of Materials Science and Chemical Engineering Ningbo University Ningbo P. R. China

2. Department of Chemistry Fudan University Shanghai P. R. China

3. National Institute of Metrology Beijing P. R. China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference34 articles.

1. The Significance of Chirality in Drug Design and Development

2. The market of chiral drugs: Chiral switches versus de novo enantiomerically pure compounds

3. The pharmaceutical industry in 2019. An analysis of FDA drug approvals from the perspective of molecules;Torre B. G.;Molecules,2020

4. https://www.fda.gov/regulatory‐information/search‐fda‐guidance‐documents/safety‐testing‐drug‐metabolites Safety Testing of Drug Metabolites Guidance for Industry. (last time accessed: Feb 20 2021).

5. FDA'S policy statement for the development of new stereoisomeric drugs

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