Affiliation:
1. Mass Spectrometry Group, Institute of Organic Chemistry Polish Academy of Sciences Warsaw Poland
Abstract
AbstractRecent advances in instrumentation and development of computational strategies for ion mobility mass spectrometry (IM‐MS) studies have contributed to an extensive growth in the application of this analytical technique to comprehensive structural description of supramolecular systems. Apart from the benefits of IM‐MS for interrogation of intrinsic properties of noncovalent aggregates in the experimental gas‐phase environment, its merits for the description of native structural aspects, under the premises of having maintained the noncovalent interactions innate upon the ionization process, have attracted even more attention and gained increasing interest in the scientific community. Thus, various types of supramolecular complexes and assemblies relevant for biological, medical, material, and environmental sciences have been characterized so far by IM‐MS supported by computational chemistry. This review covers the state‐of‐the‐art in this field and discusses experimental methods and accompanying computational approaches for assessing the reliable three‐dimensional structural elucidation of supramolecular complexes and assemblies by IM‐MS.
Subject
Spectroscopy,General Biochemistry, Genetics and Molecular Biology,Condensed Matter Physics,Analytical Chemistry
Cited by
2 articles.
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