Stir‐bar sorptive extraction based on hydroxyl‐functionalized zirconium‐metal‐organic framework for the detection of three quinolones in actual samples

Abstract

A novel analytical method based on stir‐bar sorptive extraction was proposed for the determination of three trace quinolones in fish and shrimp samples. UiO‐66‐(OH)2, a hydroxyl‐functionalized zirconium metal‐organic framework, has been coated on frosted glass rods by an in situ growth method. The product, UiO‐66‐(OH)2 modified frosted glass rods, has been characterized and key parameters have been optimized in combination with ultra‐high‐performance liquid chromatography. The detection limits of enoxacin, norfloxacin, and ciprofloxacin were 0.48–0.8 ng ml−1, and the detection concentrations were in the range of 10–300 ng ml−1, showing a good linear relationship. This method was used for the determination of three quinolones in aquatic organisms, and the recoveries in spiked fish and shrimp muscle tissue samples were 74.8%–105.4% and 82.5%–115.8%, respectively. The relative standard deviations were less than 6.9%. The established method combined stir‐bar sorptive extraction based on UiO‐66‐(OH)2 modified frosted glass rods with ultra‐high‐performance liquid chromatography, has good application prospects for the detection of quinolone residues in fish and shrimp muscle samples.