Enantioseparation of N ‐methyl duloxetine, duloxetine, and fluoxetine by countercurrent chromatography using anionic β‐cyclodextrin as chiral selector

Author:

Sun Wenyu1,Chen Ben1,You Haibo1,Fang Liqun1,Qian Junqing1,Tong Shengqiang1ORCID

Affiliation:

1. College of Pharmaceutical Science Zhejiang University of Technology Hangzhou P. R. China

Publisher

Wiley

Subject

Filtration and Separation,Analytical Chemistry

Reference35 articles.

1. Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota

2. Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine

3. LY248686, A New Inhibitor of Serotonin and Norepinephrine Uptake

4. RaoDR KankanRN.Process for preparing duloxetine and intermediates for use therein. US patent 7 645 890 publ. date January 12 2010.

5. PoggialiA PizzocaroF TubertiniP.A process for the preparation of an intermediate useful for the asymmetric synthesis of (+) duloxetine. EP patent 1 857 451 publ. date July 21 2007.

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