Crocetin ameliorates chronic restraint stress-induced depression-like behaviors in mice by regulating MEK/ERK pathways and gut microbiota

Author:

Lin Susu,Li Qiaoqiao,Jiang Shanshan,Xu Zijin,Jiang Yu,Liu Ling,Jiang Jinyan,Tong Yingpeng,Wang Ping

Funder

Science and Technology Program of Zhejiang Province

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

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3. Antidepressant effects of aqueous extract of saffron and its effects on CREB, P-CREB, BDNF, and VGF proteins in rat cerebellum;Asrari;J. Pharmacopuncture,2018

4. Evaluation of the antidepressant-like effects of acute and sub-acute administration of crocin and crocetin in mice;Bahareh;Avicenna J. Phytomed.,2015

5. Cingulate overexpression of mitogen-activated protein kinase phosphatase-1 as a key factor for depression;Barthas;Biol. Psychiatr.,2017

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