Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β 1 ‐adrenoceptor expressed in HEK‐293 cells-Reference-Cited by-同舟云学术

Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β 1 ‐adrenoceptor expressed in HEK‐293 cells

Published:2016-08-08 Issue:5 Volume:4 Page:
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Soave Mark¹,Stoddart Leigh A.¹,Brown Alastair²,Woolard Jeanette¹,Hill Stephen J.¹

Affiliation:

1. Cell Signalling and Pharmacology Research Group School of Life Sciences University of Nottingham Nottingham NG7 2UH United Kingdom

2. Heptares Therapeutics Ltd. Bio Park Welwyn Garden City AL7 3AX United Kingdom

Funder

Medical Research Council

University of Nottingham

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/prp2.250

Reference31 articles.

1. Site of Action of β-Ligands at the Human β1-Adrenoceptor

2. Agonist Actions of “β-Blockers” Provide Evidence for Two Agonist Activation Sites or Conformations of the Human β1-Adrenoceptor

3. Role of Key Transmembrane Residues in Agonist and Antagonist Actions at the Two Conformations of the Human β1-Adrenoceptor

4. Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

5. Identification of Key Residues in Transmembrane 4 Responsible for the Secondary, Low-Affinity Conformation of the Humanβ1-Adrenoceptor

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