Highly sensitive method for the determination of adenosine by LC-MS/MS-ESI: method validation and scope of application to a pharmacokinetic/pharmacodynamic study

Author:

Sharma Kuldeep1,Singh Radheraman1,Giri Sanjeev1,Rajagopal Sriram1,Mullangi Ramesh1

Affiliation:

1. Drug Metabolism and Pharmacokinetics; Jubilant Biosys Ltd; Industrial Suburb, Yeshwanthpur; Bangalore; 560 022; India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference23 articles.

1. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds;Bonfiglio;Rapid Communications in Mass Spectrometry,1999

2. A dual function for adenosine 5'-triphosphate in the regulation of vascular tone. Excitatory cotransmitter with noradrenaline from perivascular nerves and locally released inhibitory intravascular agent;Burnstock;Circulation Research,1986

3. Ion-pairing LC/MS/MS determination of nucleosides and nucleotides;Cai;Analytical Sciences,2001

4. Levels of endogenous adenosine in rat striatum. II. Regulation of basal and N-methyl- d-aspartate-induced levels by inhibitors of adenosine transport and metabolism;Delaney;Journal of Pharmacology and Experimental Therapeutics,1998

5. Adenosine and methotrexate polygluatamate concentrations in patients with juvenile arthritis;Dolezalová;Rheumatology,2005

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