Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients

Author:

Vidoni Eric D.12,Choi In‐Young1324,Lee Phil1345,Reed Gregory6,Zhang Na6,Pleen Joseph12,Mahnken Jonathan D.17,Clutton Jonathan1,Becker Annette1,Sherry Erica1,Bothwell Rebecca1,Anderson Heidi1,Harris Robert A.8,Brooks William1324,Wilkins Heather M.12,Mosconi Lisa9,Burns Jeffrey M.124,Swerdlow Russell H.1248

Affiliation:

1. University of Kansas Alzheimer's Center Fairway Kansas USA

2. Department of Neurology Kansas University Medical Center Kansas City Kansas USA

3. Hoglund Biomedical Imaging Center Kansas City Kansas USA

4. Department of Molecular and Integrative Physiology Kansas University Medical Center Kansas City Kansas USA

5. Department of Radiology Kansas University Medical Center Kansas City Kansas USA

6. Department of Pharmacology and Toxicology Kansas University Medical Center Kansas City Kansas USA

7. Department of Biostatistics Kansas University Medical Center Kansas City Kansas USA

8. Biochemistry and Molecular Biology Kansas University Medical Center Kansas City Kansas USA

9. Department of Neurology Weill Cornell Medical College New York New York USA

Funder

Alzheimer's Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference51 articles.

1. Treating Neurodegeneration by Modifying Mitochondria: Potential Solutions to a “Complex” Problem

2. Positron emission tomographic studies of aging and Alzheimer disease;Leon MJ;AJNR Am J Neuroradiol,1983

3. Positron Emission Tomography in Evaluation of Dementia

4. Altered cerebral energy metabolism in Alzheimer's disease: a PET study;Fukuyama H;J Nucl Med,1994

5. Brain Cytochrome Oxidase in Alzheimer's Disease

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