Determination of newly synthesized lipoic acid-niacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study

Author:

Chen Xiao1,Gao Jingwen1,Jiang Yiming1,Huang Ping1,Xie Yuhui2,Pi Rongbiao1,Zhu Shuzhen1,Yao Meicun1

Affiliation:

1. School of Pharmaceutical Sciences; Sun Yat-sen University; 132 Waihuan Road East, Guangzhou 510006 Higher Education Mega Center Guangzhou China

2. Food and Drug Administration of Guangdong Province; Dongfeng road 753-2, Yuexiu district Guangzhou China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference14 articles.

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2. Acute dose-dependent disposition studies of nicotinic acid in rats;Iwaki;Drug Metabolism and Disposition,1996

3. Mechanism of action of niacin;Kamanna;The American Journal of Cardiology,2008

4. The mechanism and mitigation of niacin-induced flushing;Kamanna;The International Journal of Clinical Practice,2009

5. Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC-ESI-MS/MS and its application in pharmacokinetic study;Li;Journal of Medicinal Chemistry Perspective,2012

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