Bradykinesia in Neurodegenerative Disorders: A Blinded Video Analysis of Pathology‐Proven Cases

Author:

Marsili Luca1ORCID,Duque Kevin R.1,Gregor Nathan1,Abdelghany Elhusseini1,Abanto Jesus1,Duker Andrew P.1,Hagen Matthew C.2,Espay Alberto J.1ORCID,Bologna Matteo34ORCID

Affiliation:

1. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology University of Cincinnati Cincinnati Ohio USA

2. Department of Pathology University of Cincinnati Cincinnati Ohio USA

3. Department of Human Neurosciences Sapienza University of Rome Rome Italy

4. IRCCS Neuromed Pozzilli Italy

Abstract

AbstractBackgroundBradykinesia is a cardinal feature in parkinsonisms. No study has assessed the differential features of bradykinesia in patients with pathology‐proven synucleinopathies and tauopathies.ObjectiveWe examined whether bradykinesia features (speed, amplitude, rhythm, and sequence effect) may differ between pathology‐proven synucleinopathies and tauopathies.MethodsForty‐two cases who underwent autopsy were included and divided into synucleinopathies (Parkinson's disease and dementia with Lewy bodies) and tauopathies (progressive supranuclear palsy). Two raters blinded to the diagnosis retrospectively scored the Movement Disorders Society‐Unified Parkinson's Disease Rating Scale Part III and Modified Bradykinesia Rating Scale on standardized videotaped neurological examinations. Bradykinesia scores were compared using the Mann–Whitney test and logistic regression models to adjust for disease duration.ResultsDemographic and clinical parameters were similar between synucleinopathies and tauopathies. There were no differences between speed, amplitude, rhythm, and sequence effect in synucleinopathies and tauopathies in unadjusted comparisons and adjusted models (all P > 0.05).ConclusionsClinical bradykinesia features do not distinguish the underlying neuropathology in neurodegenerative parkinsonisms. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Publisher

Wiley

Subject

Neurology (clinical),Neurology

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