A Continuous‐Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO<sub>2</sub> in Acetonitrile-Reference-Cited by-同舟云学术

A Continuous‐Flow Method for the Transformation from Amides to Nitriles Catalyzed by CeO₂ in Acetonitrile

Published:2023-05-17 Issue:10 Volume:365 Page:1618-1622
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Kobayashi Kwihwan¹^ORCID,Masuda Koichiro¹,Feng Fei¹,Rashed Md. Nurnobi¹,Sato Kazuhiko¹,Koumura Nagatoshi¹^ORCID,Kobayashi Shū¹²^ORCID

Affiliation:

1. Interdisciplinary Research Center for Catalytic Chemistry National Institute of Advanced Industrial Science and Technology Central 5 Higashi 1-1-1 Tsukuba Ibaraki 305-8565 Japan

2. Department of Chemistry School of Science The University of Tokyo Hongo, Bunkyo-ku Tokyo 111-0033 Japan

Abstract

AbstractA CeO2‐catalyzed method for the transformation from amides to nitriles was developed using acetonitrile as the solvent and dehydrating reagent. The transformation proceeded via a formal “water transfer” reaction between the amides and acetonitrile. We propose that the presence of oxygen defect sites in CeO2 is important in the mechanism of this transformation. Various nitriles could be continuously synthesized from amides in 75–96% yields via flow operation using a catalyst column packed with CeO2.

Funder

New Energy and Industrial Technology Development Organization

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202300266

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1. Transformation of Amides to Nitriles Catalyzed by CeO2 in Continuous-Flow Synthesis;Synfacts;2023-08-16