Chemo‐ and Diastereoselective Synthesis of Polyheterocycles by Rhodium(III)‐Catalyzed sp2/sp3 C−H Activation of 2‐Arylquinazolin‐4(3H)‐ones with 3‐Methylmaleimides

Abstract

AbstractRhodium(III)‐catalyzed sp2/sp3 C−H activation/annulation of 2‐arylquinazolin‐4(3H)‐ones with 3‐methylmaleimides is explored. This protocol provides diversely functionalized isoindoloquinazolinones in good yields upon reaction with various maleimides. This Rh(III)‐catalyzed protocol can be applied for the chemo‐ and diastereoselective synthesis of various polyheterocycles.magnified image