Construction of Vinyl‐Substituted<i>N</i>‐Heterocycles<i>via</i>Rh(III)‐Catalyzed C−H Functionalization/Annulation of Pyrazolidinones-Reference-Cited by-同舟云学术

Construction of Vinyl‐SubstitutedN‐HeterocyclesviaRh(III)‐Catalyzed C−H Functionalization/Annulation of Pyrazolidinones

Published:2023-01-18 Issue:2 Volume:365 Page:238-243
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Zhang Shurui¹²,Hu Shulei³⁴,Wang Kean⁵,Yang Zhao³,Liu Hong²³⁴⁵,Wang Jiang¹⁴^ORCID

Affiliation:

1. Lingang Laboratory Shanghai 200031 People's Republic of China

2. School of Life Science and Technology ShanghaiTech University Shanghai 200031 People's Republic of China

3. China Pharmaceutical University 639 Longmian Avenue Jiangning District, Nanjing 211198 People's Republic of China

4. State Key Laboratory of Drug Research Shanghai Institute of Materia Medica, Chinese Academy of Sciences 555 Zu Chong Zhi Road Shanghai 201203 People's Republic of China

5. School of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing 210023 People's Republic of China

Abstract

AbstractThe transition‐metal‐catalyzed C−H activation and annulation reactions of pyrazolidinones with 4‐vinyl‐1,3‐dioxolan‐2‐one or vinylene carbonate are described herein. This protocol provided two types of pyrazolo[1,2‐a]cinnolines as essential assets for the development of bioactive compounds, and the synthetic practicality was performed and explained with 44 examples. The possible mechanism of these two reactions is proposed based on preliminary studies and previous reports, and no oxidant was added to both reactions.

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Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202201065

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