Affiliation:
1. Parthasarathy Gandeepan Department of Chemistry Indian Institute of Technology Tirupati Yerpedu – Venkatagiri Road, Yerpedu Post Tirupati District Andhra Pradesh 517619 India
Abstract
AbstractPyrimidoindolones are an important structural motif found in many natural products and are essential to the pharmaceutical and agrochemical industry. Direct synthesis of 3,4‐unsubstituted pyrimidoindolones is not easily accessible. Here we report a rhodium(III)‐catalyzed C−H/N−H activation and annulation approach for obtaining pyrimidoindolones from N‐carbamoylindoles and vinylene carbonate. The reaction occurs at room temperature and does not require any external oxidants. A diverse spectrum of indoles were demonstrated to be viable substrates capable of producing the desired pyrimidoindolones in high yields. In addition, the reaction scope has been expanded to include pyrrole substrate. Furthermore, detailed mechanistic studies have been performed to delineate the working mode of the reaction.
Funder
Science and Engineering Research Board
Indian Institute of Technology Tirupati
Subject
General Chemistry,Biochemistry,Organic Chemistry
Cited by
1 articles.
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