Expert Consensus on the Use of <scp><i>On</i>‐Demand</scp> Treatments for <scp>OFF</scp> Episodes in Parkinson's Disease: A Modified Delphi Panel-Reference-Cited by-同舟云学术

Expert Consensus on the Use of On‐Demand Treatments for OFF Episodes in Parkinson's Disease: A Modified Delphi Panel

Published:2023-03-11 Issue:4 Volume:10 Page:652-657
ISSN:2330-1619
Container-title:Movement Disorders Clinical Practice
language:en
Short-container-title:Movement Disord Clin Pract

Author:

Isaacson Stuart H.¹,Achari Madhureeta²,Bhidayasiri Roongroj³⁴^ORCID,Comella Cynthia⁵,Farmer Jill Giordano⁶⁷,Gupta Fiona⁸,Jones Sarah⁹,Kreitzman David¹⁰,Kremens Daniel¹¹,Lewis Simon J.G.¹²,Poewe Werner¹³,Tolosa Eduardo¹⁴^ORCID,Campos Cynthia¹⁵,Gibbs Sarah N.¹⁵,Broder Michael S.¹⁵

Affiliation:

1. Parkinson's Disease and Movement Disorders Center of Boca Raton Boca Raton Florida USA

2. Integrated Neurology PA, Department of Physical Medicine and Rehabilitation McGovern Medical School, University of Texas Houston Texas USA

3. Chulalongkorn Centre of Excellence for Parkinson's Disease and Related Disorders, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society Bangkok Thailand

4. The Academy of Science The Royal Society of Thailand Bangkok Thailand

5. Department of Neurosurgery and Neurological Sciences Rush University Medical Center Chicago Illinois USA

6. Global Neuroscience Institute Pennington New Jersey USA

7. Department of Neurology Drexel College of Medicine Philadelphia Pennsylvania USA

8. Department of Neurology, Mount Sinai Medical Center Mount Sinai Beth Israel Morningside, Sinai West, The Mount Sinai Hospital New York City New York USA

9. Parkinson and Movement Disorder Alliance Tucson Arizona USA

10. Parkinson's Disease and Movement Disorders Center of Long Island Commack New York USA

11. Department of Neurology Sidney Kimmel Medical College at Jefferson University Philadelphia Pennsylvania USA

12. Brain and Mind Center, School of Medical Sciences University of Sydney Sydney New South Wales Australia

13. Department of Neurology Medical University of Innsbruck Innsbruck Austria

14. Parkinson's Disease Research Program University of Barcelona Barcelona Spain

15. PHAR Beverly Hills California USA

Abstract

ABSTRACTBackgroundOn‐demand treatments can treat OFF episodes in Parkinson's disease, however, there is limited information regarding when to prescribe them.ObjectiveDevelop expert consensus to determine appropriate clinical factors for considering on‐demand treatments.MethodsUsing a RAND/UCLA modified Delphi panel method, a panel developed consensus on the use of on‐demand treatments for OFF episodes.ResultsThe panel agreed on‐demand treatments were appropriate when OFF episodes were associated with greater functional impact and interfered with basic daily activities. The panel also agreed on‐demand treatment may be appropriate for patients with morning akinesia and/or delayed ON of first levodopa dose and >1 type of OFF episode (eg, early morning OFF or wearing OFF regardless of frequency).ConclusionsExperts agreed on‐demand treatment is appropriate for many patients with OFF episodes. The greater the functional impact of OFF episodes, the more likely experts agreed that on‐demand treatment is appropriate to prescribe.

Funder

AbbVie

ACADIA Pharmaceuticals

Acorda Therapeutics

Adamas Pharmaceuticals

Amneal

Biogen

CALA

Cerecor

Cerevel

Eli Lilly and Company

Jazz Pharmaceuticals