The prolyl hydroxylase inhibitor GSK1120360A reduces early brain injury, but protection is not maintained in a neonatal rat model of hypoxic ischaemic encephalopathy
Author:
Affiliation:
1. Department of Pharmacology, School of Medical Sciences University of New South Wales Sydney Sydney New South Wales Australia
2. Medicines Research Centre GlaxoSmithKline Stevenage UK
Funder
GlaxoSmithKline
Publisher
Wiley
Subject
Developmental Biology,Developmental Neuroscience
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jdn.10199
Reference32 articles.
1. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia
2. Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat
3. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
4. Sensorimotor Function and Neuropathology Five to Six Weeks after Hypoxia-Ischemia in Seven-Day-Old Rats
5. Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
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