Top Alzheimer's disease risk allele frequencies differ in HABS‐HD Mexican‐ versus Non‐Hispanic White Americans-Reference-Cited by-同舟云学术

Top Alzheimer's disease risk allele frequencies differ in HABS‐HD Mexican‐ versus Non‐Hispanic White Americans

Published:2023-10 Issue:4 Volume:15 Page:
ISSN:2352-8729
Container-title:Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
language:en
Short-container-title:Alz & Dem Diag Ass & Dis Mo

Author:

Housini Mohammad¹²^ORCID,Zhou Zhengyang³⁴,Gutierrez John⁵,Rao Sumedha²,Jomaa Rodwan²,Subasinghe Kumudu⁶,Reid Danielle Marie⁶,Silzer Talisa⁶,Phillips Nicole⁴⁶,O'Bryant Sid²⁴,Barber Robert Clinton²⁴,

Affiliation:

1. Department of Pharmacology and Neuroscience School of Biomedical Sciences University of North Texas Health Science Center Fort Worth Texas USA

2. Department of Family Medicine & Manipulative Medicine Texas College of Osteopathic Medicine University of North Texas Health Science Center Fort Worth Texas USA

3. Department of Biostatistics and Epidemiology School of Public Health University of North Texas Health Science Center Fort Worth Texas USA

4. Institute for Translational Research UNT Health Science Center Fort Worth Texas USA

5. Department of Internal Medicine Texas Institute for Graduate Medical Education and Research San Antonio Texas USA

6. Department of Microbiology Immunology and Genetics School of Biomedical Sciences University of North Texas Health Science Center Fort Worth Texas USA

Abstract

AbstractINTRODUCTION: Here we evaluate frequencies of the top 10 Alzheimer's disease (AD) risk alleles for late‐onset AD in Mexican American (MA) and non‐Hispanic White (NHW) American participants enrolled in the Health and Aging Brain Study–Health Disparities Study cohort.METHODS: Using DNA extracted from this community‐based diverse population, we calculated the genotype frequencies in each population to determine whether a significant difference is detected between the different ethnicities. DNA genotyping was performed per manufacturers’ protocols.RESULTS: Allele and genotype frequencies for 9 of the 11 single nucleotide polymorphisms (two apolipoprotein E variants, CR1, BIN1, DRB1, NYAP1, PTK2B, FERMT2, and ABCA7) differed significantly between MAs and NHWs.DISCUSSION: The significant differences in frequencies of top AD risk alleles observed here across MAs and NHWs suggest that ethnicity‐specific genetic risks for AD exist. Given our results, we are advancing additional projects to further elucidate ethnicity‐specific differences in AD.

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

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