Current and Next Steps Toward Prediction of Human Dose for Gene Therapy Using Translational Dose‐Response Studies-Reference-Cited by-同舟云学术

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Current and Next Steps Toward Prediction of Human Dose for Gene Therapy Using Translational Dose‐Response Studies

Published:2021-08-08 Issue:5 Volume:110 Page:1176-1179
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin Pharmacol Ther

Author:

Aksenov Sergey¹,Roberts John C.²,Mugundu Ganesh³,Mueller Karen Thudium⁴,Bhattacharya Indranil⁵,Tortorici Michael A.²

Affiliation:

1. Early Development Analytics Novartis Institutes for BioMedical Research Cambridge Massachusetts USA

2. Clinical Pharmacology and Pharmacometrics CSL Behring King of Prussia Pennsylvania USA

3. Cell Therapy Pharmacology and Modeling Takeda Pharmaceuticals International Co. Cambridge Massachusetts USA

4. Translational Sciences GentiBio Cambridge Massachusetts USA

5. Quantitative Clinical Pharmacology Takeda Pharmaceuticals International Co. Cambridge Massachusetts USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.2374

Reference10 articles.

1. Rational Clinical Dose Selection of Adeno‐Associated Virus‐Mediated Gene Therapy Based on Allometric Principles

2. Gene Therapy for Ischemic Cardiovascular Diseases: Some Lessons Learned from the First Clinical Trials

3. Interspecies scaling and comparisons in drug development and toxicokinetics

4. Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion

5. Regional angiogenesis with vascular endothelial growth factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

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1. Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety;Translational Psychiatry;2024-03-20

2. Clinical Pharmacology Perspective on Development of Adeno‐Associated Virus Vector‐Based Retina Gene Therapy;Clinical Pharmacology & Therapeutics;2024-03-07

3. Whole-Body Disposition and Physiologically Based Pharmacokinetic Modeling of Adeno-Associated Viruses and the Transgene Product;Journal of Pharmaceutical Sciences;2024-01

4. Interspecies Scaling of Transgene Products for Viral Vector Gene Therapies: Method Assessment Using Data from Eleven Viral Vectors;The AAPS Journal;2023-10-27

5. PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper;The AAPS Journal;2023-07-31

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