PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper-Reference-Cited by-同舟云学术

PK/PD and Bioanalytical Considerations of AAV-Based Gene Therapies: an IQ Consortium Industry Position Paper

Published:2023-07-31 Issue:5 Volume:25 Page:
ISSN:1550-7416
Container-title:The AAPS Journal
language:en
Short-container-title:AAPS J

Author:

Kavita Uma^ORCID,Sun Kefeng,Braun Manuela,Lembke Wibke,Mody Hardik,Kamerud John,Yang Tong-Yuan,Braun Inka V.,Fang Xiaodong,Gao Wei,Gupta Swati,Hofer Magdalena,Liao Michael Z.,Loo LiNa,McBlane Fraser,Menochet Karelle,Stubenrauch Kay-Gunnar,Upreti Vijay V.,Vigil Adam,Wiethoff Christopher M.,Xia Cindy Q.,Zhu Xu,Jawa Vibha,Chemuturi Nagendra

Publisher

Springer Science and Business Media LLC

Subject

Pharmaceutical Science

Link

https://link.springer.com/content/pdf/10.1208/s12248-023-00842-1.pdf

Reference86 articles.

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2. Elmore ZC, Oh DK, Simon KE, Fanous MM, Asokan A. Rescuing AAV gene transfer from neutralizing antibodies with an IgG-degrading enzyme. JCI. Insight. 2020;5(19)

3. Kiessling P, Lledo-Garcia R, Watanabe S, Langdon G, Tran D, Bari M, et al. The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: a randomized phase 1 study. Sci Transl Med. 2017;9(414)

4. Mingozzi F, High KA. Immune responses to AAV vectors: overcoming barriers to successful gene therapy. Blood. 2013;122(1):23–36.

5. Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: vector toolkit for human gene therapy. Mol Ther. 2006;14(3):316–27.

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