Affiliation:
1. State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 P. R. China
2. Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology (EBEAM) Chongqing Yangtze Normal University Chongqing 408100 P. R. China
Abstract
AbstractHerein, a conjugated oligomer is reported possessing a unique U‐shaped molecular geometry, which significantly affects the intramolecular charge transfer and modulates the fluorescence properties. Upon excitation, it displays blue/red dual emission, which is very sensitive to the polarity and viscosity of solvents. After being incorporated into Pluronic F127 micelles, a dramatic fluorescence enhancement is found in its red emission (up to 27‐fold) along with a stable blue emission at elevated temperature. Accordingly, the emissive micelles are successfully explored as a reliable ratiometric nanothermometer both in solution and in cellular environment. Moreover, compared to nanoparticle counterpart prepared by classical nanoprecipitation, the conjugated oligomer/F127 micelles exhibit a remarkable improvement in photo‐triggered reactive oxygen species (ROS) generation efficiency and photodynamic killing behavior on cancer cells. The current study will help researchers to further understand the structure–property relationship of π‐conjugated fluorophores and design various nanomaterials with promising potential for simultaneous diagnostic and treatment on cancers.
Funder
National Natural Science Foundation of China
Subject
Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials
Cited by
5 articles.
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