Predicting Off-Target Effects of Therapeutic Antiviral Ribonucleosides
Author:
Affiliation:
1. 201 Althouse Lab, Department of Biochemistry and Molecular Biology; The Pennsylvania State University; University Park PA USA
Publisher
John Wiley & Sons, Inc.
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/9781119329725.ch26/fullpdf
Reference43 articles.
1. A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma;Anderson;Methods,2010
2. Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides;Arnold;PLoS Pathogens,2012a
3. Human mitochondrial RNA polymerase: structure-function, mechanism and inhibition;Arnold;Biochem Biophys Acta,2012b
4. A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease;Bailey;Biochim Biophys Acta,2010
5. R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity;Bailey;Antimicrob Agents Chemother,2009
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