A transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase γ
Author:
Publisher
Elsevier BV
Subject
General Biochemistry, Genetics and Molecular Biology,Molecular Biology
Reference76 articles.
1. R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity
2. Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.
3. Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine.
4. Mitochondrial toxicity of antiviral drugs
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1. Networked Communication between Polymerase and Exonuclease Active Sites in Human Mitochondrial DNA Polymerase;Journal of the American Chemical Society;2019-06-19
2. Predicting Off-Target Effects of Therapeutic Antiviral Ribonucleosides;Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants;2018-02-23
3. Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides;PLoS Pathogens;2012-11-15
4. Human mitochondrial RNA polymerase: Structure–function, mechanism and inhibition;Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms;2012-09
5. In situ monitoring of a trace intermediate during DNA phosphorylation by T4 polynucleotide kinase for transient kinetic studies;The Analyst;2012
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