The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability-Reference-Cited by-同舟云学术

The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability

Published:2013-05-15 Issue:5-6 Volume:32 Page:459-479
ISSN:1868-1743
Container-title:Molecular Informatics
language:en
Short-container-title:Mol. Inf.

Author:

Pham-The Hai,González-Álvarez Isabel,Bermejo Marival,Garrigues Teresa,Le-Thi-Thu Huong,Cabrera-Pérez Miguel Ángel

Funder

Agencia Española de Cooperación Iberoamericana para el Desarrollo

Montaje de un laboratorio de Química Computacional, con fines académicos y científicos, para el diseño de potenciales candidatos a fármacos, en enfermedades de alto impacto social

Red-Biofarma. Red para el desarrollo de metodologías biofarmacéuticas racionales que incrementen la competencia y el impacto social de las Industrias Farmacéuticas Locales

Publisher

Wiley

Subject

Organic Chemistry,Computer Science Applications,Drug Discovery,Molecular Medicine,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/minf.201200166/fullpdf

Reference121 articles.

1. Probing the links between in vitro potency, ADMET and physicochemical parameters

2. Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial Permeability

3. An Overview of Caco‐2 and Alternatives for Prediction of Intestinal Drug Transport and Absorption

4. Permeability, Transport, and Metabolism of Solutes in Caco-2 Cell Monolayers: A Theoretical Study

5. MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

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