Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT 2 by antifolate drugs-Reference-Cited by-同舟云学术

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Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT 2 by antifolate drugs

Published:2019-06-10 Issue:14 Volume:593 Page:1863-1873
ISSN:0014-5793
Container-title:FEBS Letters
language:en
Short-container-title:FEBS Lett

Author:

Scaletti Emma¹²,Jemth Ann‐Sofie³,Helleday Thomas³⁴,Stenmark Pål¹²

Affiliation:

1. Department of Biochemistry and Biophysics Stockholm University Sweden

2. Department of Experimental Medical Science Lund University Sweden

3. Science for Life Laboratory Department of Oncology‐Pathology Karolinska Institutet Stockholm Sweden

4. Weston Park Cancer Centre Department of Oncology and Metabolism University of Sheffield UK

Funder

Vetenskapsrådet

Cancerfonden

Publisher

Wiley

Subject

Cell Biology,Genetics,Molecular Biology,Biochemistry,Structural Biology,Biophysics

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/1873-3468.13455

Reference44 articles.

1. Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families

2. Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

3. Molecular cloning, characterization and alternative splicing of the human cytoplasmic serine hydroxymethyltransferase gene

4. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy

5. Crystal structure at 2.4 Å resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate 1 1Edited by I. A. Wilson

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