Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models
Author:
Affiliation:
1. Cardiovascular and Metabolic Diseases Research Unit, Pfizer Inc.Cambridge Massachusetts USA
Publisher
Wiley
Subject
Pharmacology (medical),Modeling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12063
Reference21 articles.
1. Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
2. Next-Generation Model-Based Drug Discovery and Development: Quantitative and Systems Pharmacology
3. Sorger P.K.et al. Quantitative and systems pharmacology in the post‐genomic era: new approaches to discovering drugs and understanding therapeutic mechanisms. A NIH White Paper by the QSP Workshop Group‐October 2011 (2011).
4. A physiologically based mathematical model of integrated calcium homeostasis and bone remodeling
5. A model-based approach to investigating the pathophysiological mechanisms of hypertension and response to antihypertensive therapies: extending the Guyton model
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