Mechanistic evaluation of the effect of sodium‐dependent glucose transporter 2 inhibitors on delayed glucose absorption in patients with type 2 diabetes mellitus using a quantitative systems pharmacology model of human systemic glucose dynamics-Reference-Cited by-同舟云学术

Mechanistic evaluation of the effect of sodium‐dependent glucose transporter 2 inhibitors on delayed glucose absorption in patients with type 2 diabetes mellitus using a quantitative systems pharmacology model of human systemic glucose dynamics

Published:2020-11 Issue:8-9 Volume:41 Page:352-366
ISSN:0142-2782
Container-title:Biopharmaceutics & Drug Disposition
language:en
Short-container-title:Biopharm Drug Dispos

Author:

Mori‐Anai Kazumi¹^ORCID,Tashima Yoshihiko²,Nakada Tomohisa³^ORCID,Nakamaru Yoshinobu¹,Takahata Takayuki²,Saito Ryuta³^ORCID

Affiliation:

1. Mitsubishi Tanabe Pharma Corporation Chuo‐ku Tokyo Japan

2. Sysmex Corporation Kobe Hyougo Japan

3. Mitsubishi Tanabe Pharma Corporation Yokohama Kanagawa Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bdd.2253

Reference41 articles.

1. Inhibition of Renal Glucose Reabsorption: A Novel Strategy for Achieving Glucose Control in Type 2 Diabetes Mellitus

2. A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors

3. Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

4. Model-Based Quantification of Glucagon-Like Peptide-1–Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

5. Renal, metabolic and cardiovascular considerations of SGLT2 inhibition

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