A Quantitative Systems Pharmacology Kidney Model of Diabetes Associated Renal Hyperfiltration and the Effects of SGLT Inhibitors

Author:

Balazki Pavel123,Schaller Stephan3,Eissing Thomas1,Lehr Thorsten2

Affiliation:

1. Clinical Pharmacometrics; Bayer AG; Leverkusen Germany

2. Clinical Pharmacy; Saarland University; Saarbrücken Germany

3. esqLABS GmbH; Saterland Germany

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference43 articles.

1. Standards of Medical Care in Diabetes - 2017: Microvascular complications and foot care;Diabetes Care,2017

2. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease;Kidney Int. Suppl.,2013

3. Glomerular hyperfiltration in experimental diabetes mellitus potential role of tubular reabsorption;Vallon;J. Am. Soc. Nephrol.,1999

4. Glomerular hyperfiltration: definitions, mechanisms and clinical implications;Helal;Nat. Rev. Nephrol.,2012

5. Renal functional reserve and renal recovery after acute kidney injury;Sharma;Nephron Clin. Pract.,2014

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