Topical Silymarin Administration for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Author:

Elyasi Sepideh1,Shojaee Farzaneh Sadat Rezazadeh1,Allahyari Abolghasem2,Karimi Gholamreza3ORCID

Affiliation:

1. Department of Clinical Pharmacy, Faculty of Pharmacy; Mashhad University of Medical Sciences; Mashhad Iran

2. Hematology-Oncology Department, Faculty of Medicine; Mashhad University of Medical Sciences; Mashhad Iran

3. Pharmaceutical Research Center, Faculty of Pharmacy; Mashhad University of Medical Sciences; Mashhad Iran

Funder

Mashhad University of Medical Sciences

Research Council of Mashhad University of Medical Sciences

Publisher

Wiley

Subject

Pharmacology

Reference49 articles.

1. Incidence and severity of hand-foot syndrome in colorectal cancer patients treated with capecitabine: a single-institution experience;Abushullaih;Cancer Invest,2002

2. Treatment of chemotherapy-induced oral mucositis by silymarin;Altaei;J Bagh College Dentistry,2012

3. Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors;Asgari;J Cutan Pathol,1999

4. Anti-inflammatory effects of silymarin against damages caused by UV irradiation;Athari;Global Veterinaria,2012

5. Significant association between hand-foot syndrome and efficacy of capecitabine in patients with metastatic breast cancer;Azuma;Biol Pharm Bull,2012

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