Affiliation:
1. Institute for NanoScale Science and Technology Medical Device Research Institute College of Science and Engineering Flinders University Bedford Park SA 5042 Australia
2. Biomedical Nanoengineering Laboratory College of Medicine and Public Health Flinders University Bedford Park SA 5042 Australia
3. College of Veterinary Medicine Jilin Provincial Engineering Research Center of Animal Probiotics Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding Engineering Research Center of Microecological Vaccines (Drugs) for Major Animal Diseases Ministry of Education Jilin Agricultural University Changchun 130118 China
Abstract
AbstractSurgical site infections (SSI) are major post‐operative complications following surgery. Reducing SSI is a global urgency as they account for huge pecuniary, physiological, and emotional burdens for patients. Antibiotic resistance is the main challenge for surgeons dealing with SSIs. Aggregation‐induced emission photosensitisers (AIE PS) with their distinct optical characteristics, biocompatibility, low toxicity, and target specificity, hold the potential for the treatment of SSI. Herein, a synergetic strategy combining plasma polymerization and AIE PS is adopted to develop coatings that can eradicate SSI‐causing bacteria. These coatings can preferentially kill Gram‐negative and Gram‐positive bacteria over mammalian cells after triggered by light irradiation. The cell viability and immunostaining studies confirmed their biocompatibility on mammalian cells. The antibacterial mechanistic studies explored their ability to generate reactive oxygen species (ROS), which is crucial for overcoming antibiotic resistance. Thus, this study opens an avenue toward antibacterial coatings to decrease the prevalence of SSI.
Funder
Australian National Fabrication Facility
China Scholarship Council
Australian Research Council
National Health and Medical Research Council
Cited by
4 articles.
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