Affiliation:
1. Institute of Chemistry and The Center for Nanoscience and Nanotechnology The Hebrew University of Jerusalem Jerusalem 91904 Israel
2. College of Food Science and Technology Huazhong Agricultural University Wuhan Hubei 430070 P. R. China
3. Key Laboratory of Environment Correlative Dietology Huazhong Agricultural University Ministry of Education Wuhan Hubei 430070 P. R. China
Abstract
AbstractAntiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA‐Phe‐NH2 and DOPA‐Phe(4F)‐NH2 that can self‐assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL−1, for DOPA‐Phe‐NH2 and DOPA‐Phe(4F)‐NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop‐casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.
Funder
China Scholarship Council
Subject
Mechanical Engineering,Mechanics of Materials
Cited by
2 articles.
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