Antiviral drug discovery: preparing for the next pandemic

Author:

Adamson Catherine S.12345ORCID,Chibale Kelly678910ORCID,Goss Rebecca J. M.11312135ORCID,Jaspars Marcel141516175,Newman David J.18192021ORCID,Dorrington Rosemary A.22232410ORCID

Affiliation:

1. School of Biology

2. Biomedical Sciences Research Complex

3. University of St Andrews

4. St Andrews KY16 9ST

5. UK

6. Drug Discovery and Development Centre (H3D) and South African Medical Research Council Drug Discovery and Development Research Unit

7. Department of Chemistry and Institute of Infectious Disease and Molecular Medicine

8. University of Cape Town

9. Rondebosch 7701

10. South Africa

11. School of Chemistry

12. North Haugh

13. St Andrews

14. Marine Biodiscovery Centre

15. Department of Chemistry

16. University of Aberdeen

17. Old Aberdeen

18. Retired Chief

19. Natural Products Branch, NIH/NCI

20. Frederick National Laboratory

21. USA

22. Dept. of Biochemistry and Microbiology

23. Rhodes University

24. Makhanda (Grahamstown)

Abstract

SARS-CoV-2, EBOV and emerging RNA viruses are amongst the most important global health threats; yet clinically approved antiviral drugs are available for only 10 of the more than 220 viruses known to infect humans.

Funder

South African Medical Research Council

Medical Research Council

Department of Health & Social Care

National Department of Health

Newton Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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