Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin-Reference-Cited by-同舟云学术

Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin

Published:2019-02-20 Issue:6 Volume:14 Page:673-685
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Van Lam van Thuy¹,Ivanova Teodora¹,Hardes Kornelia¹,Heindl Miriam Ruth²,Morty Rory E.³,Böttcher‐Friebertshäuser Eva²,Lindberg Iris⁴,Than Manuel E.⁵,Dahms Sven O.⁶,Steinmetzer Torsten¹^ORCID

Affiliation:

1. Institute of Pharmaceutical ChemistryPhilipps University Marbacher Weg 6 35032 Marburg Germany

2. Institute of VirologyPhilipps University Hans-Meerwein-Str. 2 35043 Marburg Germany

3. Department of Lung Development and RemodellingMax Planck Institute for Heart and Lung Research Bad Nauheim Germany

4. Department of Anatomy and NeurobiologyUniversity of Maryland Medical School Baltimore MD 21201 USA

5. Protein Crystallography GroupLeibniz Institute on Aging—Fritz Lipmann Institute Beutenbergstr. 11 07745 Jena Germany

6. Department of BiosciencesUniversity of Salzburg Billrothstrasse 11 5020 Salzburg Austria

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800807

Reference52 articles.

1. Peptide therapeutics: current status and future directions

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3. Design and synthesis of potent and selective macrocyclic thrombin inhibitors

4. Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors

5. Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa–Tissue Factor Complex

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