Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin-Reference-Cited by-同舟云学术

Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

Published:2018-10-09 Issue:21 Volume:13 Page:2266-2270
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Jumde Varsha R.¹²^ORCID,Mondal Milon¹^ORCID,Gierse Robin M.¹²³^ORCID,Unver M. Yagiz¹,Magari Francesca⁴,van Lier Roos C. W.¹,Heine Andreas⁴^ORCID,Klebe Gerhard⁴^ORCID,Hirsch Anna K. H.¹²³^ORCID

Affiliation:

1. Chemical BiologyStratingh Institute for ChemistryUniversity of Groningen Nijenborgh 7 9747 AG Groningen The Netherlands

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)—Helmholtz Centre for Infection Research (HZI)Department of Drug Design and Optimization (DDOP) Campus Building E8.1 66123 Saarbrücken Germany

3. Department of PharmacySaarland University, Saarbrücken Campus Building E8.1 66123 Saarbrücken Germany

4. Drug Design Group AG KlebeInstitute of Pharmaceutical Chemistry Marbacher Weg 6 35032 Marburg Germany

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800446

Reference40 articles.

1. Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly