Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes-Reference-Cited by-同舟云学术

Structural States of Hdm2 and HdmX: X‐ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes

Published:2019-05-27 Issue:14 Volume:14 Page:1305-1314
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kallen Joerg¹^ORCID,Izaac Aude¹,Chau Suzanne¹,Wirth Emmanuelle¹,Schoepfer Joseph²^ORCID,Mah Robert²,Schlapbach Achim²,Stutz Stefan²,Vaupel Andrea²,Guagnano Vito²,Masuya Keiichi³,Stachyra Therese‐Marie⁴,Salem Bahaa²,Chene Patrick⁴,Gessier Francois²,Holzer Philipp²,Furet Pascal²

Affiliation:

1. Chemical Biology & TherapeuticsNovartis Institutes for BioMedical Research Novartis Campus 4002 Basel Switzerland

2. Global Discovery ChemistryNovartis Institutes for BioMedical Research Novartis Campus 4002 Basel Switzerland

3. Present address: Peptidream Inc. Menguro Tokyo Japan

4. Disease Area OncologyNovartis Institutes for BioMedical Research Novartis Campus 4002 Basel Switzerland

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900201

Reference47 articles.

1. The p53 pathway: positive and negative feedback loops

2. p53, guardian of the genome

4. The p53–Mdm2 module and the ubiquitin system

5. The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

Cited by 21 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cellular, Structural Basis, and Recent Progress for Targeting Murine Double Minute X (MDMX) in Tumors;Journal of Medicinal Chemistry;2024-08-26

2. Targeting Hdm2 and Hdm4 in Anticancer Drug Discovery: Implications for Checkpoint Inhibitor Immunotherapy;Cells;2024-06-29

3. Synthesis and biological evaluation of 4-imidazolidinone–containing compounds as potent inhibitors of the MDM2/p53 interaction;European Journal of Medicinal Chemistry;2024-04

4. Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein–Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy;Journal of Medicinal Chemistry;2023-12-07

5. Targeting Biomolecular Condensation and Protein Aggregation against Cancer;Chemical Reviews;2023-06-28