Discovery of 1-Hydroxypyridine-2(1H )-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor-Reference-Cited by-同舟云学术

Discovery of 1-Hydroxypyridine-2(1H )-thione-6-carboxylic Acid as a First-in-Class Low-Cytotoxic Nanomolar Metallo β-Lactamase Inhibitor

Published:2017-05-22 Issue:11 Volume:12 Page:845-849
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Shin Woo Shik¹,Bergstrom Alexander²,Bonomo Robert A.³,Crowder Michael W.²,Muthyala Ramaiah⁴^ORCID,Sham Yuk Yin¹⁵^ORCID

Affiliation:

1. Center for Drug Design & Bioinformatics and Computational Biology, Program; University of Minnesota; Minneapolis MN 55455 USA

2. Department of Chemistry and Biochemistry; Miami University; Oxford OH 45056 USA

3. Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center; Cleveland OH 44106 USA

4. Department of Experimental and Clinical Pharmacology & Center for Orphan Drug Research; University of Minnesota; Minneapolis MN 55455 USA

5. Current address: Department of Integrative Biology & University of Minnesota Informatics Institute; University of Minnesota; Minneapolis MN 55455 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference25 articles.

1. Three Decades of β-Lactamase Inhibitors

2. Metallo-β-lactamase structure and function

3. Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

4. Coordination Geometries of Metal Ions in D- or L-Captopril-inhibited Metallo-β-lactamases

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