Tracking Hidden Binding Pockets Along the Molecular Recognition Path ofl‐Trp to Indoleamine 2,3‐Dioxygenase 1-Reference-Cited by-同舟云学术

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Tracking Hidden Binding Pockets Along the Molecular Recognition Path ofl‐Trp to Indoleamine 2,3‐Dioxygenase 1

Published:2019-11-14 Issue:24 Volume:14 Page:2084-2092
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Greco Francesco A.¹,Albini Elisa²,Coletti Alice¹,Dolciami Daniela¹,Carotti Andrea¹,Orabona Ciriana²,Grohmann Ursula²,Macchiarulo Antonio¹^ORCID

Affiliation:

1. Department of Pharmaceutical SciencesUniversity of Perugia via del liceo n.1 06123 Perugia Italy

2. Department of Experimental MedicineUniversity of Perugia P.le Gambuli 06132 Perugia Italy

Funder

European Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900529

Reference59 articles.

1. Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

2. Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

3. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

4. Structural and functional analyses of human tryptophan 2,3-dioxygenase

5. Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Critical Assessment of a Structure-Based Screening Campaign for IDO1 Inhibitors: Tips and Pitfalls;International Journal of Molecular Sciences;2022-04-02

2. Structural Basis of Selective Human Indoleamine‐2,3‐dioxygenase 1 (hIDO1) Inhibition;ChemMedChem;2021-07-29

3. One Key and Multiple Locks: Substrate Binding in Structures of Tryptophan Dioxygenases and Hydroxylases;ChemMedChem;2021-07-16

4. Indoleamine 2,3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme;The FEBS Journal;2021-06-19

5. Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site;International Journal of Tryptophan Research;2021-01

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