Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding-Reference-Cited by-同舟云学术

Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding

Published:2015-09-18 Issue:11 Volume:10 Page:1884-1891
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Marzinzik Andreas L.¹,Amstutz René¹²,Bold Guido¹,Bourgier Emmanuelle¹,Cotesta Simona¹,Glickman J. Fraser¹³,Götte Marjo¹,Henry Christelle¹,Lehmann Sylvie¹,Hartwieg J. Constanze D.¹,Ofner Silvio¹,Pellé Xavier¹,Roddy Thomas P.¹⁴,Rondeau Jean-Michel¹,Stauffer Frédéric¹,Stout Steven J.¹⁵,Widmer Armin¹,Zimmermann Johann¹⁶,Zoller Thomas¹,Jahnke Wolfgang¹

Affiliation:

1. Novartis Institutes for BioMedical Research; Basel 4002 Switzerland

2. Conim AG; Oberwiler Kirchweg 4c 6300 Zug Switzerland

3. High Throughput and Spectroscopy Resource Center; Rockefeller University; New York NY 10065 USA

4. Agios; Cambridge MA 02139-4169 USA

5. Merck Research Laboratories; 126 E. Lincoln Avenue Rahway NJ 07065 USA

6. Polyphor; Hegenheimermattweg 125 4123 Allschwil Switzerland

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201500338/fullpdf

Reference40 articles.

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5. Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

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