Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA-Reference-Cited by-同舟云学术

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA

Published:2018-02-19 Issue:7 Volume:13 Page:672-677
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Prati Federica¹²,Zuccotto Fabio¹,Fletcher Daniel¹,Convery Maire A.³,Fernandez-Menendez Raquel²,Bates Robert²,Encinas Lourdes²,Zeng Jingkun³,Chung Chun-wa³,De Dios Anton Paco²,Mendoza-Losana Alfonso²,Mackenzie Claire¹,Green Simon R.¹,Huggett Margaret¹,Barros David²,Wyatt Paul G.¹^ORCID,Ray Peter C.¹^ORCID

Affiliation:

1. Drug Discovery Unit, College of Life Sciences; University of Dundee; Dow Street Dundee DD1 5EH Scotland UK

2. DPU TB Diseases of the Developing World; Tres Cantos Medicines Development Campus; GlaxoSmithKline Severo Ochoa 2 Tres Cantos 28760 Madrid Spain

3. Platform Technology and Sciences; Medicines Research Centre, GlaxoSmithKline; Gunnels Wood Road Stevenage Herts SG1 2NY Hertfordshire UK

Funder

Seventh Framework Programme

Tres Cantos Open Lab Foundation

Medical Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference40 articles.

1. Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

2. functional group http://goldbook.iupac.org/html/F/F02555.html

3. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

4. Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

5. Deconstructing fragment-based inhibitor discovery

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