Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface-Reference-Cited by-同舟云学术

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Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

Published:2012-10 Issue:10 Volume:19 Page:1300-1312
ISSN:1074-5521
Container-title:Chemistry & Biology
language:en
Short-container-title:Chemistry & Biology

Author:

Van Molle Inge,Thomann Andreas,Buckley Dennis L.,So Ernest C.,Lang Steffen,Crews Craig M.,Ciulli Alessio

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference52 articles.

1. Deconstructing fragment-based inhibitor discovery;Babaoglu;Nat. Chem. Biol.,2006

2. Fragment-based deconstruction of Bcl-xL inhibitors;Barelier;J. Med. Chem.,2010

3. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant;Basse;Chem. Biol.,2010

4. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly;Braisted;J. Am. Chem. Soc.,2003

5. Targeting the von Hippel-Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction;Buckley;J. Am. Chem. Soc.,2012

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