A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition-Reference-Cited by-同舟云学术

A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition

Published:2018-06-01 Issue:13 Volume:13 Page:1303-1307
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Favalli Nicholas¹^ORCID,Biendl Stefan¹,Hartmann Marco¹,Piazzi Jacopo²,Sladojevich Filippo³,Gräslund Susanne⁴⁵,Brown Peter J.⁴,Näreoja Katja⁵,Schüler Herwig⁵,Scheuermann Jörg¹^ORCID,Franzini Raphael¹⁶^ORCID,Neri Dario¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences; ETH Zürich; Vladimir-Prelog-Weg 4 8093 Zürich Switzerland

2. Philochem AG; Liebernstrasse 3 8112 Otelfingen Switzerland

3. Roche Pharma Research and Early Development; Roche Innovation Center Basel, F. Hoffmann-La, Roche Ltd.; Grenzacherstrasse 124 4070 Basel Switzerland

4. Structural Genomics Consortium (SGC); University of Toronto; Toronto ON M5G 1L7 Canada

5. Department of Structural Biology; Department of Medical Biochemistry and Biophysics (MBB); Karolinska Institutet; Scheeles väg 2 17177 Stockholm Sweden

6. College of Pharmacy; University of Utah; 30 South 2000 East Salt Lake City UT 84112 USA

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

European Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference37 articles.

1. Encoded combinatorial chemistry.

2. Encoded Library Technology Screening of Hepatitis C Virus NS4B Yields a Small-Molecule Compound Series withIn VitroReplicon Activity

3. Nucleic Acid-programmed Assemblies: Translating Instruction into Function in Chemical Biology

4. Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery

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