Optimization of Substrate-Analogue Furin Inhibitors-Reference-Cited by-同舟云学术

Optimization of Substrate-Analogue Furin Inhibitors

Published:2017-11-16 Issue:23 Volume:12 Page:1953-1968
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Ivanova Teodora¹,Hardes Kornelia¹,Kallis Stephanie²³,Dahms Sven O.⁴⁵,Than Manuel E.⁴,Künzel Sebastian⁶,Böttcher-Friebertshäuser Eva⁷,Lindberg Iris⁸,Jiao Guan-Sheng⁹¹⁰,Bartenschlager Ralf²³,Steinmetzer Torsten¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry; Philipps University; Marbacher Weg 6 35032 Marburg Germany

2. Department of Infectious Diseases, Molecular Virology; Heidelberg University; Im Neuenheimer Feld 345 69120 Heidelberg Germany

3. German Center for Infection Research, Heidelberg Partner Site; Im Neuenheimer Feld 345 69120 Heidelberg Germany

4. Protein Crystallography Group; Leibniz Institute on Aging-Fritz Lipmann Institute; Beutenbergstr. 11 07745 Jena Germany

5. Department of Molecular Biology; University of Salzburg; Billrothstrasse 11 5020 Salzburg Austria

6. Faculty of Engineering Sciences; Hochschule Ansbach; Residenzstraße 8 91522 Ansbach Germany

7. Institute of Virology; Philipps University; Hans-Meerwein-Str. 2 Marburg Germany

8. Department of Anatomy and Neurobiology; University of Maryland Medical School; Baltimore MD 21201 USA

9. Department of Chemistry; Hawaii Biotech, Inc.; Honolulu HI USA

10. MedChem ShortCut LLC; Pearl City HI USA

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference74 articles.

1. Furin at the cutting edge: From protein traffic to embryogenesis and disease

2. The biology and therapeutic targeting of the proprotein convertases

3. Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase

4. In Vivo Evidence That Furin from Hepatocytes Inactivates PCSK9

5. The Proprotein Convertase (PC) PCSK9 Is Inactivated by Furin and/or PC5/6A

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